HAN-P-19
Young-Tae Chang
POSTECH
Professor
South Korea
Chemical Based Aging Research, Fluorescent Cell Imaging Probe, Sensor
Academic Career
BS, 1991, POSTECH; PhD, 1995, POSTECH (advisor: Sung-Kee Chung); Postdoctral Training, 1997-2000, UC Berkeley & Scripps (advisor: Prof. Peter Schultz); Assistant Professor, 2000-2005, NYU; Associate Professor, 2005-2017, NYU; Associate Professor, 2007-2012, NUS; Professor, 2012-2017, NUS; Professor, 2017-present, POSTECH
Selected Publications
Development of a Mature B Lymphocyte Probe through Gating-Oriented Live-Cell Distinction (GOLD) and Selective Imaging of Topical Spleen, Cho, H.; Kwon, H. Y.; Kim, Y.; Kim, K.; Lee, E. J.; Kang, N. Y.; Chang, Y. T.* JACS Au 2024, 4, 1450-1457.
Theranostics application of tumor-initiating cell probe TiY in non-small cell lung cancer, Lee, Y. A.; Lek, C. C. J.; Rong, G. Wu, Z; Shathishwaran, S.; Lee, J. H. J.; Tam, W. L.; Wuestefeld, T.; Park, S. J.; Jung, S.; Kim, B.; Kang, N. Y.*; Chang, Y. T.* Theranostics 2023, 13, 1370-1380.
Development of a Fluorescent Probe for M2 Macrophages via Gating-Oriented Live-Cell Distinction, Cho, H.; Kwon, H. Y.; Lee, S. H.; Lee, H. G.; Kang, N. Y.*; Chang, Y. T.* J. Am. Chem. Soc. 2023, 145, 2951-2957.
Visualizing inflammation with an M1 macrophage selective probe via GLUT1 as the gating target, Cho, H.; Kwon, H. Y.; Sharma, A.; Lee, S. H.; Liu, X.; Miyamoto, N.; Kim, J. J., Im, S. H.; Kang, N. Y.; Chang, Y. T .* Nat. Commun. 2022, 13:5974
A SLC35C2 transporter-targeting fluorescent probe for the selective detection of B lymphocytes identified by SLC-CRISPRi and unbiased fluorescence library screening, Gao, M.; Lee, S. H.; Das, R. K.; Kwon, H. Y.; Kim, H. S.; Chang, Y. T.* Angew. Chem. Int. Ed. Engl. 2022, 61, 202202095
Fluorescent probe strategy for live cell distinction, Liu, X.; Chang, Y. T.* Chem. Soc. Rev. 2022, 51, 1573-1591
Neutrophil Selective Fluorescent Probe Development through Metabolism-Oriented Live-cell Distinction, Gao, M.; Lee, S. H.; Park, S. H.; Ciaramicoli, L. M.; Kwon, H. Y.; Cho, H.; Jeong, J.; Chang, Y. T.* Angew. Chem. Int. Ed. Engl. 2021, 60, 23742-23749.
Lipid-Oriented Live-Cell Distinction of B and T Lymphocytes, Kwon, H. Y.; Kumar Das, R.; Jung, G. T.; Lee, H. G.; Lee, S. H.; Berry, S. N.; Tan, J. K. S.; Park, S.; Yang, J. S.; Park, S.; Baek, K.; Park, K. M.; Lee, J. W.; Choi, Y. K.; Kim, K. H.; Kim, S.; Kim, K. P.; Kang, N. Y.*; Kim, K.*; Chang, Y. T.* J. Am. Chem. Soc. 2021, 143, 5836-5844.
Why My Lab?
If you come to my lab, you can learn the mechanism of aging and new method how to reverse aging, using fluorescent imaging probes and chemical biology approach. You will be an expert in fluorescent probe development, bioimaging & chemical-based aging research.
