HAN-P-26
Xiaoguang Lei
Peking University
Professor
China
Chemical Biology, Drug Discovery, Biocatalysis, Natural Product Research, Organic Synthesis
Academic Career
Prof. Xiaoguang Lei obtained BS in chemistry from Peking University in 2001 and a Ph.D. in organic synthesis from Boston University under the supervision of Prof. John Porco in 2006. Then he conducted postdoc work in bioorganic chemistry with Prof. Samuel Danishefsky at Columbia University from 2006 to 2008. In early 2009, he returned to China. He started his independent career as a Principal Investigator and Director of the Chemistry Center at the National Institute of Biological Sciences (NIBS) in Beijing. In early 2014, he received a tenured full professorship from Peking University and moved to the College of Chemistry at Peking University. Now he is the Boya Distinguished Professor of Chemistry and Chemical Biology and a senior PI of the Peking-Tsinghua Center for Life Sciences.
Selected Publications
Pei Mia, et al., Xiaoguang Lei* “A widespread plant defense compound disarms bacterial type III injectisome assembly” Science 2024, in press
Jun Yang, et al., Xiaoguang Lei* “Structure-guided discovery of bile acid derivatives for treating liver diseases without causing itch” Cell 2024, 187, 1-19
Haoran Dong, et al., Xiaoguang Lei* “Chemoenzymatic Total Synthesis of Alchivemycin A” Nature Synthesis, 2024, 3, 1124-1133
Bin Jiang, et al., Xiaoguang Lei*, Jianbin Yan* “Characterization and heterologous reconstitution of Taxus biosynthetic enzymes leading to baccatin III” Science 2024, 383, 622-629
Kai Wang, et al., Xiaoguang Lei*, Jie Qiao*, Changtao Jiang* “Microbial-host-isozyme analyses reveal microbial DPP4 inhibition as a potential antidiabetic target” Science 2023, 381, eadd5787
Junping Fan, et al., Xiaoguang Lei* “Structural basis of TRPV3 inhibition by an antagonist” Nature Chemical Biology 2023, 19, 81-90
Lei Gao, et al., Xiaoguang Lei* "FAD-dependent Enzyme-Catalysed Intermolecular [4+2] Cycloaddition in Natural Product Biosynthesis" Nature Chemistry, 2020, 12, 620-628
Sun, L.; et al.; Lei, X.*; Wang, X.* “Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase” Cell 2012, 148, 213-227"
Why My Lab?
We are a world-leading lab for chemical biology, organic synthesis, biocatalysis and drug discovery. We offer full scholarships for all students and postdocs.
