HAN-P-02
Kazuya Kikuchi
Osaka University
Professor
Japan
Fluorescent Probes, Molecular Imaging, MRI
Academic Career
B.S., 1988, Univ. of Tokyo; Ph.D., 1994, Univ. Of Tokyo (advisor: Masaaki Hirobe); Postdoctoral Training, 1994-1995, UCSD (advisor: Roger Y. Tsien), 1995-1996, the Scripps Research Institute (advisor: Donald Hilvert); Assistant Professor, 1997-2000, Univ. Of Tokyo; Associate Professor, 2000-2005, Univ. of Tokyo; Professor, 2005-present, Osaka University; Distinguished Professor, 2017-present, Osaka University
Selected Publications
T. Nonomura, M. Minoshima, K. Kikuchi, “Light-Activated Gene Expression System Using a Caging-Group-Free Photoactivatable Dye”, Angew. Chem. Int. Ed., 63, e202416420 (2024).
Konishi, Y., Minoshima, M., Fujihara, K., Uchihashi, T. *Kikuchi, K. Elastic Polymer-coated Nanoparticles with Fast Clearance for 19FMR Imaging. Angew. Chem. Int. Ed., 62, e202308565 (2023).
Minoshima, M., Umeno, T., Kadooka, K., Roux, M., Yamada, N. *Kikuchi, K. Development of a Versatile Protein Labeling Tool for Live-Cell Imaging Using Fluorescent ß-Lactamase Inhibitors. Angew. Chem. Int. Ed., 62, e202301704 (2023).
Imoto, T., Minoshima, M., Yokoyama, T., Emery, B., Bull, S.D., Bito, H. *Kikuchi, K. A Photodeactivatable Antagonist for Controlling CREB Dependent Gene Expression. ACS Cent. Sci., 6, 1813-1818 (2020).
Hashimoto, R., Minoshima, M., Kikuta, J., Yari, S., Bull, S.D., Ishii, M., *Kikuchi, K. An Acid Activatable Fluorescence Probe for Imaging Osteocytic Bone Resorption Activity in Deep Bone Cavities. Angew. Chem. Int. Ed., 59, 20996-21000 (2020).
Minoshima, M., Kikuta, J., Omori, Y., Seno, S., Suehara, R., Maeda, H., Matsuda, H., Ishii, M., *Kikuchi, K. In vivo Multicolor Imaging with Fluorescent Probes Revealed the Dynamics and Function of Osteoclast Proton Pumps. ACS. Cent. Sci. 5, 1059-1066 (2019).
Hori, Y., Otomura, N., Nishida, A., Nishiura, M., *Kikuchi, K. Synthetic-Molecule/Protein Hybrid Probe with Fluorogenic Switch for Live-Cell Imaging of DNA Methylation. J. Am. Chem. Sci. 140, 1686-1690 (2018).
Akazawa, K., Sugihara, F., Nakamura, T., Matsushita, H., Mukai, H., Akimoto, R., Minoshima, M., Mizukami., S., *Kikuchi, K. Perfluorocarbon‐Based 19F MRI Nanoprobes for In Vivo Multicolor Imaging. Angew. Chem. Int. Ed. 130, 16984-16989 (2018).
Why My Lab?
My lab can offer experiences of real biology experiments using the own chemical tool synthesized by graduate students by themselves.
