HAN-P-36
Doron Shabat
Tel Aviv University
Professor
Israel
Chemiluminescence, Molecular Probes, 1,2-Dioxetanes
Academic Career
Doron Shabat studied chemistry at the Technion-Israel Institute of Technology between 1987 and 1990. After obtaining his B.Sc. degree, he continued toward his Ph.D. degree. Upon the completion of his Ph.D. thesis in 1997, he joined the Scripps Research Institute in La Jolla, California as a postdoctoral fellow. In 2000, he returned to Israel to start his independent career in the School of Chemistry at Tel Aviv University as a senior lecturer. He was promoted to the rank of associate professor in 2005 and to full professor in 2008.
Selected Publications
Green, O., Eilon, T., Hananya, N., Gutkin, S., Bauer, CR., Shabat, D. “Opening a Gateway for Chemiluminescence Cell Imaging: Distinctive Methodology for Design of Bright Chemiluminescent Dioxetane Probes”, ACS Cent. Sci., 2017, 4, 349-58.
Tannous, R., Shelef, O., Gutkin, S., David, M., Leirikh, T., Ge, L., Jaber, J., Zhou, Q., Ma, P., Fridman, M., Spitz, U., Houk, K.N., Shabat, D., “Spirostrain-Accelerated Chemiexcitation of Dioxetanes Yields Unprecedented Detection Sensitivity in Chemiluminescence Bioassays”, ACS. Cent. Sci., 2024, 10, 28–42.
David, M., Leirikh, T., Shelef, O., Gutkin, S., Kopp, T., Zhou, Q., Ma, P., Fridman, M., Houk, K.N., Shabat. D., “Chemiexcitation Acceleration of 1, 2-Dioxetanes via a Spiro-Fused Inductive Electron-Withdrawing Motifs”, Angew. Chem., 2024, doi.org/10.1002/anie.202410057.
Shelef, O., Kopp, T., Tannous, T., Jospe-Kaufman, M., Arutkin, M., Reuveni, S., Shabat, D., Fridman, M. “Enzymatic Activity Profiling Using an Ultra-Sensitive Array of Chemiluminescent Probes for Bacterial Classification and Characterization”, J. Am. Chem. Soc., 2024, 146, 5263–5273.
Why My Lab?
My lab has expertise in molecular probes design with a particular interest in chemiluminescence.
